PREVENTIVE ONCOLOGY RESEARCH
Molecular Diagnostic Unit is now offering BCR-ABL Quantitative service to patients
Department of Preventive Oncology Research was established in 2013. It is a department focussing on integrated aspects of cancer genomics and precision oncology. The department focus is Oncology based molecular research, molecular diagnostics and molecular prevention based activities.
Mission of the Dept of Preventive Oncology Research is to achieve highest standards in the practice of Oncological Sciences and to strive for promoting patient health and safety.
Vision of the Dept of Preventive Oncology Research is
MOLECULAR DIAGNOSTICS FROM PREVENTIVE ONCOLOGY MOLECULAR TESTING LABORATORY (POMT)
The department is accredited by NABL for medical testing and offers molecular diagnostics and precision oncology services for hospital patients. The list of services is appended below.
Research Activities – Ongoing Projects
Dr. Vijayalakshmi (PI) secured the grant titled “Development of a Therapeutic resistance and relapse prediction model for paediatric acute lymphoblastic leukaemia using artificial Intelligence techniques.” Funding agency – ICMR, Amount – Rs 51,00,000 Co -investigators – Dr Raghunathan Rengaswamy, AI expert from Robert Bosch Centre for Data Science and AI (RBCDSAI) IIT-Madras and Dr. Venkataraman (Prof and Head, Dept of Medical Oncology), Dr. Swaminathan, (Associate Director, HOD, Tumour Registry and Epidemmiology)
Development of dual color plasmonic immunoassay for visual detection of Salivary Vimentin for early diagnosis of Oral Cancer
Dr. Vijayalakshmi (PI) secured the grant titled – “Development of Dual color plasmonic immunoassay for visual detection of salivary vimentin for early diagnosis of oral cancer”. Funding agency – SERB (CRG) Amount – Rs 48,00,000 Co Investigators – Prof Arvind Krishnamurthy (Prof and Head, Dept of Surgical Oncology, Cancer Institute (W.I.A) and Dr. Divyambika Srinivas, (Prof, Dept of Oral Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai).
Dr Vijayalakshmi (Co-PI) for a grant titled “Oral microbiota and early oral cancer (MICRO-ORAL): A pilot study to standardize sequencing of oral microbiota in saliva samples” a collaborative study with Public Health Foundation of India (PHFI)
Dr Vijayalakshmi (Co-PI) for a grant titled Bioprinting a novel polymer-based 3D nanocomposite scaffolds coated with anti-cancer drug for oral tumour model. (Ad-Hoc ICMR)
Dr Vijayalakshmi (Co-PI) for grant titled – Genetic and Proteomic expression profiling in clinical stages of Oral Submucous Fibrosis patients. Funding agency – ICMR (2021-2014) Amount : Rs 23,75,000 (Ad-Hoc ICMR 2021-14385)
Dr Vijayalakshmi (Co-PI) for grant titled – Development of novel nano-silymarin gel for therapeutic efficiacy in oral submucosal fibrosis. Funding Agency – ICMR (2022-2025) Amount : Rs 33,41,130 (No.5/4/2-4/Oral Health/2021-NCD-II)
Dr Sridevi Duggirala (PI), Dr Vijayalakshmi (Co-PI) for grant titled – Study of PAK1 inhibitors in PDX derived Lung Cancers – Rs, 15,00,000 (DBT, TARE)Dr Vidyarani Shyamsundar (PI), Dr Vijayalakshmi (Co-PI) for grant titled – Study of role of Beta Blockers in cancer of the Gingivobuccal Cancers – Rs 15,00,000 (DBT-TARE)
RESEARCH PROJECTS COMPLETED PREVIOUSLY
Title of Project
Source of Funds
(from – to — )
VALIDATION OF THE SNPS INVOLVED IN PROMOTING GENETIC SUSCPETIBILITY TO ORAL CANCER AMONG LONG TERM TOBACCO CHEWERS IDENTIFIED IN NORTH EASTERN AND SOUTHERN INDIAN POPULATION
A STUDY OF BRAF MUTATIONS AND PROMOTER METHYATION OF GENES ASSOCIATED WITH THYROID CANCERS
QUANTITATIVE TISSUE PROTEOMICS OF ORAL TONGUE SQUAMOUS CELL CARCINOMA (MENTOR)
|PROJECT TITLE||FUNDING AGENCY|
|Genetic and Proteomic Profiling of Oral Submucous Fibrosis||ICMR, GOVT OF INDIA|
|Formulation and Characterisation of Nanosilymarin gel and its applications in Oral Submucous Fibrosis||ICMR, GOVT OF INDIA|
|Study of PAK1 inhibitors in PDX derived Lung Cancers||DBT, TARE|
|Study of role Beta Blockers in cancers of gingivobuccal cancers||DBT, TARE|
|Developing AI based models for relapse prediction in pediatric ALL||ICMR, GOVT OF INDIA|
|Detecting early cervical cancer in Indian women using a multi-biomarker panel (the CARE study)||Public Health Research Institute of India(PHRI, Mysore)|
|Study of salivary biomarkers in oral cancer||PHFI, INDIA|
|Study of Oral microbiome by 16S RNA sequencing||PHFI, INDIA|
Clinical Trials Involved:
|Phase IIb/III study to determine efficacy of Curcumin (formulation) and Metformin to reduce the incidence of second primary tumors of aerodigestive tract in patients with history of head and neck squamous cell carcinoma. (SPT TRIAL)||National Cancer Grid|
Student Activities : Internship Programs
|INTERNSHIP TYPE (CURRENT)||STUDENT AND INSTITUTION INVOLVED|
|6 MONTHS PROGRAM||MR PRUTHWEESH, B.TECH BIOTECH, VIT, VELLORE|
|6 MONTHS PROGRAM||HEMAPRIYA, B.TECH BIOTECH, VEL TECH, CHENNAI|
Routine Worshops Conducted:
List Of Staff Members :
Dr R Vijayalakshmi, M.Sc., Ph.D.
Miss Soundharya Ravindran B. Tech (Genetic Engg)., MS.
(Cancer Biology, UK)
Mrs A Kanchana M.Sc., DMLT.
Miss Afrose Fathima B.Sc., DMLT.
Dr Sridevi Duggirala M.Sc., Ph.D.
Mr Aravindalochan M.Tech
Miss M.Latha, B.Sc., DMLT.
Mrs G Komathi, M.Sc., M.Phil., MBA.
Mr K. Mehanathan M.Sc.
Miss B.Nishanthi B.Sc., DMLT.
List Of Ph.d Scholars (ongoing)
Dr Vani Suresh, MDS.
Dr Vidyarani Shyamsundar MDS.
LIST OF PH.D. PROGRAMS COMPLETED UNDER THE SUPERVISION OF DR R VIJAYALAKSHMI – 4
Other Honours - Dr R Vijayalakshmi
Member Of Professional Bodies
Accomplishments from the Department :
Best Research Paper with Gold Medal at International Conference conducted by Foundation of Head and Neck Oncology (FHNO-2022) for presentation titled “Vimentin as a biomarker for Oral Cancer” (Dr R Vijayalakshmi)
Best Research Paper with Gold Medal at International Conference conducted by Foundation of Head and Neck Oncology (FHNO-2014) for presentation titled “Risk Stratification of Oral Tongue Cancers” (Dr R Vijayalakshmi)
Best Research paper with Cash award – Development of paper based microfluidic based device for detection of HR HPV during screening of cervical cancer (Dr Sridevi Duggirala)
Best Research with Cash award – Cervical cancer screening using HPV DNA testing (Ms Soundarya Ravindran)
Second Prize for Research Paper – Role of SNP in carcinogenesis of gingiva- buccal cancers among long term tobacco chewers (Dr Vidyarani Shyamsundar)
List Of Publications
CUMULATIVE IMPACT FACTOR OF JOURNAL PUBLICATION – 130.538
Ramshankar, V.; Ravindran, S.; Arun, K.; Albert, K.; Sri, S.L.; Ramasubramanian, L.; Satyaseelan, B. Impact of HPV Molecular Testing with Partial Genotyping as a Feasibility Study in Cervical Cancer Community Screening Program in South India. Journal of Medical Virology 2023, 95, e28715, doi:10.1002/jmv.28715. (Impact Factor – 20.693)
Divyambika Catakapatri Venugopal, Reshma Devi Senthilnathan, Saba Maanvizhi, Yasasve Madhavan , Sathasivasubramanian Sankarapandian,Vijayalakshmi Ramshankar and Mangathayaru Kalachaveedu. Preparation and Characterization of Silymarin Gel: A Novel Topical Mucoadhesive Formulation for Potential Applicability in Oral Pathologies. Gels 2023, 9(2), 139; https://doi.org/10.3390/gels9020139 IF – 4.432
Sharbadeb Kundu 1, Bishal Dhar 2, Raima Das 3, Shaheen Laskar 3, Seram Anil Singh 4, Wetetsho Kapfo 5, Rajesh Paul 6, Vijayalakshmi Ramshankar 7, Yashmin Choudhury 3, Sankar Kumar Ghosh. The impact of prehistoric human dispersals In the presence of tobacco-related oral cancer in Northeast India
Gene. 2022 Mar 1;813:146098. doi: 10.1016/j.gene.2021.146098.
PMID: 34952175 DOI: 10.1016/j.gene.2021.146098 IF – 3.913
Abirami Moorthy 1, Divyambika Catakapatri Venugopal 1, Vidyarani Shyamsundar 2, Yasasve Madhavan 1, Soundharya Ravindran 3, Mehanathan Kuppuloganathan 3, Arvind Krishnamurthy 4, SathasivasubramanianSankarapandian 1, Vani anapathy 5, Vijayalakshmi Ramshankar 3 Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics (Basel), 2022 Aug 11;12(8):1935. doi: 10.3390/diagnostics12081935. IF – 3.992
Ananthi Sivagnanam 1, Vidyarani Shyamsundar 2, Pallavi Kesavan 1, Arvind Krishnamurthy 3, Soundara Viveka Thangaraj 1, Divyambika Catakapatri Venugopal 4, Hemashree Kasirajan 5, Pratibha Ramani 5, Vinutha Rachapudi Sarma 6, Vijayalakshmi Ramshankar 1 2D-DIGE-Based Proteomic Profiling with Validations Identifies Vimentin as a Secretory Biomarker Useful for Early Detection and Poor Prognosis in Oral Cancers J Oncol, 2022. Apr 22;2022: 4215097. doi: 10.1155/2022/4215097. eCollection 2022. PMID 35498535 IF – 4.375
Divyambika CV, Sathasivasubramanian S, Vidyarani S, RaviDavid A, Harinee S, Vijayalakshmi R. Clinicopathological Correlation of Cyclooxygenase 2 Expression in Oral Submucous Fibrosis: An Immunohistochemical Study. J Int Soc Prev Community Dent. 2021 Sep 21;11(5):553-560. eCollection 2021 Sep-Oct. PMID: 34760800
Vidyarani Shyamsundar 1, Soundara Viveka Thangaraj 2, Arvind Krishnamurthy 3, Sanjana Vimal 2, Pallavi Kesavan 2, Aravinda Babu 1, Masthan Kmk 1, Vijayalakshmi Ramshankar 2Exome Sequencing with Validations and Expression of p16/CDKN2A Shows no Association with HPV in Oral Cancers. Asian Pac J Cancer Prev,. 2022 Jan 1;23(1):191-200. doi: 10.31557/APJCP.2022.23.1.191. PMID 35092388 IF-2.514
Venugopal DC, Ravindran S, Shyamsundar V, Sankarapandian S, Krishnamurthy A, Sivagnanam A, Madhavan Y, Ramshankar V. Integrated Proteomics Based on 2D Gel Electrophoresis and Mass Spectrometry with Validations: Identification of a Biomarker Compendium for Oral Submucous Fibrosis-An Indian Study. J Pers Med 2022 Feb 3;12(2):208.doi: 10.3390/jpm12020208. PMID 35207696 IF-4.945
Thangaraj SV, Shyamsundar V, Krishnamurthy A, Ramshankar V. Deregulation of extracellular matrix modeling with molecular prognostic markers revealed by transcriptome sequencing and validations in Oral Tongue squamous cell carcinoma. Sci Rep. 2021, Jan 8;11(1):250. doi: 10.1038/s41598-020-78624- 4. PMID: 33420101 IF-4.38
Thambiraj S, Shruthi S, Vijayalakshmi R, Ravishankaran D. Evaluation of cytotoxic activity of docetaxel loaded gold nanoparticles for lung cancer drug delivery. Cancer Treat Res Commun 2019, Jul 10,21:100157. Doi:10.1016/j.ctarc 2019.100157. PMID 31310876
Durai L, Vijayalakshmi R, Karunagaran D.A novel reporter system for cyclic AMP mediated gene expression in mammalian cells based on synthetic transgene expression system. Eur J Pharmacol. 2019 Jul 15;855:56-64. Epub 2019 Apr 26. PMID:31034821 IF-4.432
Latha Durai 1, Soundharya Ravindran 1, Krishnamurthy Arvind 2, Devarajan Karunagaran 3, Ramshankar Vijayalakshmi 4 Synergistic effect of metformin and vemurufenib (PLX4032) as a Molecular targeted therapy in anaplastic thyroid cancer: an in vitro study. Mol Biol Rep, 2021, 48(11), 7443-7446 (Impact Factor – 2.742)
Zargar S, Tomar V, Shyamsundar V, Vijayalakshmi R, Somasundaram K, Karunagaran D.A Feedback Loop between MicroRNA 155 (miR-155), Programmed Cell Death 4, and Activation Protein 1 Modulates the Expression of miR-155 and Tumorigenesis in Tongue Cancer. Mol Cell Biol. 2019 Mar 1;39(6). pii: e00410-18. PMID:30617160 IF-4.272
Kundu S, Ramshankar V, Verma AK, Thangaraj SV, Krishnamurthy A, Kumar R, Kannan R, Ghosh SK Association of DFNA5, SYK, and NELL1 variants along with HPV infection in oral cancer among the prolonged tobacco-chewers. Tumour Biol. 2018 Aug;40(8):1010428318793023. PMID:30091681 IF-3.65
Chakraborty D, Viveka TS, Arvind K, Shyamsundar V, Kanchan M, Alex SA, Chandrasekaran N, Vijayalakshmi R, Mukherjee AA facile gold nanoparticle- based ELISA system for detection of osteopontin in saliva: Towards oral cancer diagnostics. Clin Chim Acta, 2018, Feb 477: 166-172 PMID 28917507 IF-3.786
- Krishnamurthy A, Ramshankar V, Murherkar K, Vidyarani S, Raghunandhan GC, Das A, Desai PB, Albert K Role and relevance of BRAF mutations in risk stratifying patients of papillary thyroid cancers along with a review of literature. Indian J Cancer. 2017 Jan-Mar;54(1):372-378. PMID:29199726 IF-1.224
Das A, Krishnamurthy A, Ramshankar V, Sagar TG, Swaminathan R.The increasing challenge of never smokers with adenocarcinoma lung: Need to look beyond tobacco exposure.Indian J Cancer. 2017 Jan-Mar;54(1):172-177. doi: 10.4103/ijc.IJC_33_17.PMID:29199684 IF-1.224
Kumar AS, Jagadeeshan S, Pitani RS, Ramshankar V, Venkitasamy K, Venkatraman G, Rayala SK.Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis. Mol Cell Biol. 2017 Mar 1;37(6). pii: e00510-16. doi: 10.1128/MCB.00510-16. PMID:27956702 IF-4.272
Krishnamurthy A, Ramshankar V, Murherkar K, Vidyarani S, Raghunandhan GC, Das A, Desai PB, Albert K.Role and relevance of BRAF mutations in risk stratifying patients of papillary thyroid cancers along with a review of literature. Indian J Cancer. 2017 Jan-Mar;54(1):372-378. doi: 10.4103/ijc.IJC_182_17. PMID:29199726 IF-1.224
Viveka TS, Shyamsundar V, Krishnamurthy A, Ramani P, Ramshankar V p53 expression helps identify high risk oral tongue pre-malignant lesions and correlates with patterns of invasive tumour front and tumour depth in oral tongue squamous cell carcinoma. Asian Pac J Cancer Preventtion , 2016, 17(1), 189-95. PMID 26838208 IF-2.514
Krishnamurthy A, Soundara V, Ramshankar V. Preventive and Risk reduction strategies for women at high risk of developing breast cancer : a Review. Asian Pac J Cancer Prev 2016, 17(3), 895-904. PMID 27039715 IF-2.514
Krishnamurthy A, Majhi U, Rangarajan GK, Ramshankar V, Kumar RK.The diagnostic and therapeutic challenges in the management of a double giant parathyroid adenoma. Indian J Nucl Med. 2016 Oct-Dec;31 (4):301-304. PMID:27833320
Thangaraj SV, Shyamsundar V, Krishnamurthy A, Ramani P, Ganesan K, Muthuswami M, Ramshankar V. Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations. PLoS One. 2016 Jun 9; 11 (6):e0156582. PMID: 27280700 IF 3.24
Don KR, Ramani P, Ramshankar V, Sherlin HJ, Premkumar P, Natesan A. Promoter hypermethylation patterns of P16, DAPK and MGMT in oral squamous cell carcinoma: a systematic review and meta-analysis. Indian J Dent Res. 2014 Nov-Dec;25(6):797-805. doi: 10.4103/0970-9290.152208. PMID: 25728117
Maremanda NG, Roy K, Kanwar RK, Shyamsundar V, Ramshankar V, Krishnamurthy A, Krishnakumar S, Kanwar JR Quick chip assay using locked nucleic acid modified epithelial cell adhesion molecule and nucleolin aptamers for the capture of circulating tumor cells. Biomicrofluidics. 2015 Sep 29;9(5):054110.PMID: 26487896 IF-2.8
Ramshankar V, Soundara VT, Malliga JS, Kothandaraman Murugan, Albert K, Krishnamurthy A, Use of Fast transfer analysis cartridges for cervical sampling and real time PCR based High Risk HPV testing in Cervical Cancer Prevention- a feasibility study from South India, Asia Pac J Cancer Prev, 2015, 16(14):5993- 9 PMID – 26320486 IF 2.514
Ramshankar V, Soundara VT, Shyamsundar V, Ramani P, Krishnamurthy A. Risk Stratification of Early Stage Oral Tongue Cancers Based on HPV Status and p16 immunoexpression. Asian Pac J Cancer Prev. 2014;15 (19):8351-9. PMID:25339028 IF-2.514
Thangaraj Soundara Viveka, Krishnamurthy Arvind, Ramshankar Vijayalakshmi. Microarray Applications in Cancer Biology – the challenges. J Biological Scientific Opinion, 2013, vol 1(2), 117-122.
Krishnamurthy A, Ramshankar V. Early stage oral tongue cancer among non- tobacco users–an increasing trend observed in a South Indian patient population presenting at a single centre. Asian Pac J Cancer Prev. 2013;14(9):5061-5.PMID:24175776 IF 2.514
Krishnamurthy A, Ramshankar V, Majhi U. Organ conservation approach for primary mucosal malignant melanoma of the larynx. J Cancer Res Ther. 2013 Oct-Dec;9 (4):758-9. doi: 10.4103/0973-1482.126495. PMID:24518742 IF-1.805
Vijayalakshmi Ramshankar, Arvind Krishnamurthy. Chemoprevention of Oral Cancer – green tea experience. Natural science Biology and Medicine, 2013, J Nat Sci Biol Med. 2014 Jan;5 (1):3-7. doi: 10.4103/0976-9668.127272. Review.PMID:24678188
Vijayalakshmi Ramshankar, Arvind Krishnamurthy. Lung Cancer Detection by screening – presenting circulating miRNAs as a promising breakthrough. Asia Pacific Journal of Cancer Prevention, 2013, 14(4), 2167-2172. PMID 23725107 IF2.514
Vijayalakshmi Ramshankar, Arvind Krishnamurthy, Human Papilloma virus in Head and Neck Cancers – Role and Relevance in Clinical Management. Indian Journal of Surgical Oncology, 2012 DOI 10.1007/s13193-012-0196-5. PMID 24426701
Sabitha K and Vijayalakshmi R, “Finding new inhibitors of EML4-ALK fusion protein – A Computational approach. International Research Journal of Pharmacy, 2012, 3(3), 171-176.
Krishnamurthy A, Vijayalakshmi R, “ Non Smoking associated lung cancer in India – A Single Centre experience, Indian Journal of Cancer 2012, vol 49, 82- 88. PMID 22842173 IF 1.224
- Vijayalakshmi R, Sabitha K, Arvind K, “How dissimilarly similar are Biosimilars? “ International Research Journal of Pharmacy 2012.
Babu Jully, Vijayalakshmi R, Gopisetty Gopal, Kesavan Sabitha, Thangarajan Rajkumar Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing’s Sarcoma in vitro. BMC Cancer, 2012, 12, 513 PMID 2314599 IF 4.4
VijayalakshmiR and Krishnamurthy A. “Targetable Driver Mutations in Non Small Cell Lung Cancer, Indian Journal of Surgical Oncology, 2011, vol-2, no- 3, 178-188.
Krishnamurthy A, Vijayalakshmi N, Mahji U “ A Fatal Case of pure giant cell carcinoma of the lung” J Cancer Res Ther, 2011, 7(3), 363-5. PMID 22044828 IF 1.805
T Rajkumar, K Sabitha, Vijayalakshmi N, S Shirley, G Selvalakshmi, Mayilvahanan B “ Identification and Validation of genes involved in cervical tumorigenesis “ BMC Cancer 2011, feb 22, 11, 80. PMID 21338529 IF-4.4
T Rajkumar, Vijayalakshmi N, G Gopal, K Sabitha, S Shirley, U Mahalingaraja, AS Ramakrishnan “ Identification and Validation of genes involved in gastric tumorigenesis” Cancer Cell International, 2010, Nov 24, 10; 45. PMID 21092330 IF 5.149
T. Rajkumar, Vijayalakshmi N, K Sabitha, S Shirley, G Selvalakshmi, Mayil Vahanan Bose, Lavanya Nambaru “ A 7 gene expression score predicts for radiation response in cancer cervix” BMC Cancer (2009), 9, 365- 375 PMID 19832977 IF 4.4
Vijayalakshmi N, B Jully, K Sabitha, T Rajkumar “Computational Prediction of Structure of EWS-FLI1 fusion protein” Bioinformatics Trends, 2009, 4, 53-61.
Vijayalakshmi N, G.Selvalakshmi, U.Mahji, T.Rajkumar “ Alterations found in p16/Rb/CyclinD1 pathway in the Dysplastic and Malignant cervical epithelium” Oncology Research (2007), vol 16, 527-533 PMID 18306932
T.Rajkumar and Vijayalakshmi N “Is there a Role for surrogate Markers of Pre- Malignant lesions of Cervix in India?” Proc Indian nat Sci Acad. (2003) B-69, 73-82
Vijayalakshmi.N, G.Selvalakshmi, U.Mahji,T.Rajkumar “c-Myc oncoprotein expression and prognosis in patients with Carcinoma of the cervix: An Immunohistochemical study” in European Journal of Gynecological Oncology, (2002), XXIII, 135-138. PMID-12013111 IF 0.196
T.Rajkumar and Vijayalakshmi N “Molecular Aspects of cervical cancer” Proceedings of Asian Pacific Journal for Cancer Prevention, (2000) Vol- I, APCC supplement, 15-17.
- Vijayalakshmi R , Krishnamurthy A. Book Chapter titled Therapeutically relevant “Driver mutations” in Non Small cell lung cancer in Lung Cancer Update 2012 Monograph. Text book of Academic College of Physicians of India, Indian College of Physicians. 2012, 167-177.
Vijayalakshmi R. Conference Handout titled “ PCR Principles and its applications” in I Midterm National Conference of IAOMP, 2013.
Thangaraj Soundara Viveka, Krishnamurthy Arvind , Shyamsundar Vidyarani, Ramshankar Vijayalakshmi* Updates in Human Papilloma Virus. Recent Advances in Cervical Cancer. Avid Science, Berlin, Germany.
Arvind Krishnamurthy, Ujjwala Prakash, Lalitha Ramasubramanian and Vijayalakshmi Ramshankar. Recent advances and reviews of Research in cervical cancer treatment. Recent Advances in Cervical Cancer. Avid Science, Berlin, Germany.
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