● B.Sc – Microbiology, MKU / The American College.
● M.Sc – Immunology & Microbiology, MKU / The American College.
● M.Phil – Biotechnology, TANUVAS / Madras Veterinary College.
● PhD – Molecular Oncology, University of Madras / Cancer Institute (WIA).
● Biomarker discovery, evaluation, and validation
● Translational diagnostics
● Microbiome and Metagenomics
● AMR
My primary research focus is on identification of biomarkers for early diagnosis and therapeutic targets in cervical and colorectal cancer. We have developed a Double antibody sandwich ELISA (DAS-ELISA) for p16 which would help screen women for cervical dysplasia and cancer. This technology is now transferred to HLL Lifecare Limited, (A Government of India Enterprise). As a Principal investigator and a member of the International Large Bowel Microbiome Disease Network I have been investigating the colorectal ‘microbiome’. A wide range of diseases are associated with large bowel dysbiosis. Our network in Collaboration University of Leeds (UK), has helped to generate India specific CRC microbiome data. We are currently expanding these data with specific focus on microbiome and metabolome in Early onset colorectal cancer (EOCRC).
Funded by: Cancer Research UK
This project aims to identify CRC-associated pathogen/toxin carriage and develop a microbiome-based CRC screening test.
Funded by: DBT/Wellcome India Alliance Team Science Grant
This project aims to comprehensively study the genetic events along with the role of microbiome and metabolome that may drive CRC in the young.
Funded by: ICMR-CAR
This project aims to develop and clinically validate the p16-based ELISA kit for cervical cancer screening.
1. Krishnan, S. R., Sharma, D., Nazeer, Y., Bose, M., Rajkumar, T., Jayaraman, G., Madaboosi, N., & Gromiha, M. M. (2024). rAbDesFlow: a novel workflow for computational recombinant antibody design for healthcare engineering. Antibody therapeutics, 7(3), 256-265. https://doi.org/10.1093/abt/tbae018
2. Bose, M., Wood, H. M., Young, C., International C. R. C. Microbiome Network (AMS/CRUK), Quirke, P., & Seshadri, R. A. (2023). Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts. BMC microbiology, 23(1), 52. https://doi.org/10.1186/s12866-023-02805-0
3. Bose, M., Sunder Singh, S., Ganesharaja, S., Chiwate, A. S., Hingmire, S. J., & Rajkumar, T. (2023). Development and Evaluation of p16 based Double Antibody Sandwich ELISA for Detection of Cervical Precancer and Cancer. Asian Pacific journal of cancer prevention : APJCP, 24(7), 2337–2346. https://doi.org/10.31557/APJCP.2023.24.7.2337
4. Kumari, S., Saha, U., Bose, M., Murugan, D., Pachauri, V., Sai, V. V. R., & Madaboosi, N. (2023). Microfluidic Platforms for Single Cell Analysis: Applications in Cellular Manipulation and Optical Biosensing. Chemosensors, 11(2), 107. https://doi.org/10.3390/chemosensors11020107
5. Dhandapani, H., Bose, M., & Kesavan, S. (2022). The Immune-related ceRNA Network in Prognosis of Cervical Cancer. Asian Pacific journal of cancer prevention: APJCP, 23(10), 3347–3354. https://doi.org/10.31557/APJCP.2022.23.10.3347
6. Young, C., Wood, H. M., Seshadri, R. A., Van Nang, P., Vaccaro, C., Melendez, L. C., Bose, M., Van Doi, M., Piñero, T. A., Valladares, C. T., Arguero, J., Balaguer, A. F., Thompson, K. N., Yan, Y., Huttenhower, C., & Quirke, P. (2021). The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries. Genome medicine, 13(1), 27. https://doi.org/10.1186/s13073-021-00844-8
7. Ammothumkandy, A., Maliekal, T. T., Bose, M. V., Rajkumar, T., Shirley, S., Thejaswini, B., Giri, V. G., & Krishna, S. (2016). CD66 and CD49f expressing cells are associated with distinct neoplastic henotypes and progression in human cervical cancer. European journal of cancer (Oxford, England : 1990), 60, 166–178. https://doi.org/10.1016/j.ejca.2016.03.072
8. Bose, M. V., & Rajkumar, T. (2015). Assessment of the radiation sensitivity of cervical cancer cell lines. Methods in molecular biology (Clifton, N.J.), 1249, 351–362. https://doi.org/10.1007/978-1-4939-2013-6_26
9. Bose, M. V., Gopisetty, G., Selvaluxmy, G., & Rajkumar, T. (2012). Dominant negative Ubiquitin-conjugating enzyme E2C sensitizes cervical cancer cells to radiation. International journal of radiation biology, 88(9), 629–634. https://doi.org/10.3109/09553002.2012.702299
10. Rajkumar, T., Sabitha, K., Vijayalakshmi, N., Shirley, S., Bose, M. V., Gopal, G., & Selvaluxmy, G. (2011). Identification and validation of genes involved in cervical tumourigenesis. BMC cancer, 11, 80. https://doi.org/10.1186/1471-2407-11-80
11. Rajkumar, T., Vijayalakshmi, N., Sabitha, K., Shirley, S., Selvaluxmy, G., Bose, M. V., & Nambaru, L. (2009). A 7 gene expression score predicts for radiation response in cancer cervix. BMC cancer, 9, 365. https://doi.org/10.1186/1471-2407-9-365
Ph.D. (Computational Biology)
PEACOCC project
Research AssociateMy role in this project is to develop bioinformatics - NGS pipelines using 16S rRNA gene sequencing and shotgun metagenomics datasets and to characterize the gut microbiome profiles of colorectal cancer (CRC) patients and healthy volunteers. Additionally, we employ machine learning (ML), deep learning approaches to identify potential biomarkers that could facilitate the early detection of CRC.MSc. Genomics
PEACOCC project
Project Associate (PhD scholar)My role in this project is to characterize the faecal microbiome associated with Early-onset colorectal cancer (EOCRC) and understand how it differs from the microbiome found in the normal population (healthy volunteers). In addition, I plan to study CRC-associated pathogen and their toxin carriage.MSc. Biochemistry
PEACOCC project
Research Assistant (PhD scholar)My role in this project is to characterize the faecal metabolome associated with Early-onset colorectal cancer (EOCRC) and understand how metabolites differ between the normal populations (healthy volunteers) and EOCRC cases. In addition, I plan to study the influence of these microbial metabolites in EOCRC.We are looking for prospective PhD candidates who comes with own fellowship including
Inspire / DBT JRF/ ICMR-JRF / CSIR – NET Fellowship to join our team.
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