Molecular Diagnostic Unit is now offering BCR-ABL Quantitative service to patients
of the Dept of Preventive Oncology Research is
The department is accredited by NABL for medical testing and offers molecular diagnostics and precision oncology services for hospital patients. The list of services is appended below.
Please feel welcome to contact our friendly reception staff with any general or medical enquiry call us.
Research Activities – Ongoing Projects
|PROJECT TITLE||FUNDING AGENCY|
|Genetic and Proteomic Profiling of Oral Submucous Fibrosis||ICMR, GOVT OF INDIA|
|Formulation and Characterisation of Nanosilymarin gel and its applications in Oral Submucous Fibrosis||ICMR, GOVT OF INDIA|
|Study of PAK1 inhibitors in PDX derived Lung Cancers||DBT, TARE|
|Study of role Beta Blockers in cancers of gingivobuccal cancers||DBT, TARE|
|Developing AI based models for relapse prediction in pediatric ALL||ICMR, GOVT OF INDIA|
|Detecting early cervical cancer in Indian women using a multi-biomarker panel (the CARE study)||Public Health Research Institute of India(PHRI, Mysore)|
|Study of salivary biomarkers in oral cancer||PHFI, INDIA|
|Study of Oral microbiome by 16S RNA sequencing||PHFI, INDIA|
Clinical Trials Involved:
|Phase IIb/III study to determine efficacy of Curcumin (formulation) and Metformin to reduce the incidence of second primary tumors of aerodigestive tract in patients with history of head and neck squamous cell carcinoma. (SPT TRIAL)||National Cancer Grid|
Student Activities : Internship Programs
|INTERNSHIP TYPE (CURRENT)||STUDENT AND INSTITUTION INVOLVED|
|6 MONTHS PROGRAM||MR PRUTHWEESH, B.TECH BIOTECH, VIT, VELLORE|
|6 MONTHS PROGRAM||HEMAPRIYA, B.TECH BIOTECH, VEL TECH, CHENNAI|
Routine Worshops Conducted:
List Of Staff Members :
Dr R Vijayalakshmi, M.Sc., Ph.D.
Miss Soundharya Ravindran B. Tech (Genetic Engg)., MS.
(Cancer Biology, UK)
Mrs A Kanchana M.Sc., DMLT.
Miss Afrose Fathima B.Sc., DMLT.
Dr Sridevi Duggirala M.Sc., Ph.D.
Mr Aravindalochan M.Tech
Miss M.Latha, B.Sc., DMLT.
Miss Rachel Gnanamani, MA.
Mrs G Komathi, M.Sc., M.Phil., MBA.
Mr K. Mehanathan M.Sc.
Miss B.Nishanthi B.Sc., DMLT.
List Of Ph.d Scholars (ongoing)
Dr Vani Suresh, MDS.
Dr Vidyarani Shyamsundar MDS.
Dr Divyambika Srinivas MDS.
Other Honours - Dr R Vijayalakshmi
Member Of Professional Bodies
Accomplishments from the Department :
Best Research Paper with Gold Medal at International Conference conducted by Foundation of Head and Neck Oncology (FHNO-2022) for presentation titled “Vimentin as a biomarker for Oral Cancer” (Dr R Vijayalakshmi)
Best Research Paper with Gold Medal at International Conference conducted by Foundation of Head and Neck Oncology (FHNO-2014) for presentation titled “Risk Stratification of Oral Tongue Cancers” (Dr R Vijayalakshmi)
Best Research paper with Cash award – Development of paper based microfluidic based device for detection of HR HPV during screening of cervical cancer (Dr Sridevi Duggirala)
Best Research with Cash award – Cervical cancer screening using HPV DNA testing (Ms Soundarya Ravindran)
Second Prize for Research Paper – Role of SNP in carcinogenesis of gingiva- buccal cancers among long term tobacco chewers (Dr Vidyarani Shyamsundar)
List Of Publications
Cumulative Impact Factor for publications (Dr Vijayalakshmi – 110.149) (Publications – LAST 2 YEARS)
Sharbadeb Kundu 1, Bishal Dhar 2, Raima Das 3, Shaheen Laskar 3, Seram Anil Singh 4, Wetetsho Kapfo 5, Rajesh Paul 6, Vijayalakshmi Ramshankar 7, Yashmin Choudhury 3, Sankar Kumar Ghosh. The impact of prehistoric human dispersals In the presence of tobacco-related oral cancer in Northeast India
Gene. 2022 Mar 1;813:146098. doi: 10.1016/j.gene.2021.146098.
PMID: 34952175 DOI: 10.1016/j.gene.2021.146098 IF – 3.913
Abirami Moorthy 1, Divyambika Catakapatri Venugopal 1, Vidyarani Shyamsundar 2, Yasasve Madhavan 1, Soundharya Ravindran 3, Mehanathan Kuppuloganathan 3, Arvind Krishnamurthy 4, Sathasivasubramanian Sankarapandian 1, Vani Ganapathy 5, Vijayalakshmi Ramshanka Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics (Basel), 2022 Aug 11;12(8):1935. doi: 10.3390/diagnostics12081935. IF – 3.992
Ananthi Sivagnanam 1, Vidyarani Shyamsundar 2, Pallavi Kesavan 1, Arvind Krishnamurthy 3, Soundara Viveka Thangaraj 1, Divyambika Catakapatri Venugopal 4, Hemashree Kasirajan 5, Pratibha Ramani 5, Vinutha Rachapudi Sarma 6, Vijayalakshmi Ramshankar 1 2D-DIGE-Based Proteomic Profiling with Validations Identifies Vimentin as a Secretory Biomarker Useful for Early Detection and Poor Prognosis in Oral Cancers J Oncol, 2022. Apr 22;2022: 4215097. doi: 10.1155/2022/4215097. eCollection 2022. PMID 35498535 IF – 4.375
Divyambika CV, Sathasivasubramanian S, Vidyarai S, RaviDavid A, Harinee S, Vijayalakshmi R. ⦁ Clinicopathological Correlation of Cyclooxygenase 2 Expression in Oral Submucous Fibrosis: An Immunohistochemical Study. J Int Soc Prev Community Dent. 2021 Sep 21;11(5):553-560. eCollection 2021 Sep-Oct. PMID: 34760800
Vidyarani Shyamsundar 1, Soundara Viveka Thangaraj 2, Arvind Krishnamurthy 3, Sanjana Vimal 2, Pallavi Kesavan 2, Aravinda Babu 1, Masthan Kmk 1, Vijayalakshmi Ram shankar 2Exome Sequencing with Validations and Expression of p16/CDKN2A Shows no Association with HPV in Oral Cancers. Asian Pac J Cancer Prev,. 2022 Jan 1;23(1):191-200. doi: 10.31557/APJCP.2022.23.1.191. PMID 35092388 IF-2.514
Venugopal DC, Ravindran S, Shyamsundar V, Sankarapandian S, Krishnamurthy A, Sivagnanam A, Madhavan Y, Ramshankar V. Integrated Proteomics Based on 2D Gel Electrophoresis and Mass Spectrometry with Validations: Identification of a Biomarker Compendium for Oral Submucous Fibrosis-An Indian Study. J Pers Med 2022 Feb 3;12(2):208.doi: 10.3390/jpm12020208. PMID 35207696 IF-4.945
Thangaraj SV, Shyamsundar V, Krishnamurthy A, Ramshankar V. Deregulation of extracellular matrix modeling with molecular prognostic markers revealed by transcriptome sequencing and validations in Oral Tongue squamous cell carcinoma. Sci Rep. 2021, Jan 8;11(1):250. doi: 10.1038/s41598-020-78624- 4. PMID: 33420101 IF-4.38
S Thambiraj 1, R Vijayalakshm i 2, D Ravi Shankaran 3 An effective strategy for development of docetaxel encapsulated gold nanoformulations for treatment of prostate cancer. Sci Rep 2021, Feb 2; 11(1) : 2808. doi: 10.1038/s41598-020- 80529-1. PMID: 3353152 IF-4.38
Thambiraj S, Shruthi S, Vijayalakshmi R, Ravishankaran D. Evaluation of cytotoxic activity of docetaxel loaded gold nanoparticles for lung cancer drug delivery. Cancer Treat Res Commun 2019, Doi:10.1016/j.ctarc 2019.100157. PMID 31310876 IF-1.98
Durai L, Vijayalakshmi R, Karunagaran D.A novel reporter system for cyclic AMP mediated gene expression in mammalian cells based on synthetic transgene expression system. Eur J Pharmacol. 2019 Jul 15;855:56-64. Epub 2019 Apr 26. PMID:31034821 IF-4.432
Zargar S, Tomar V, Shyamsundar V, Vijayalakshmi R, Somasundaram K, Karunagaran D. A Feedback Loop between MicroRNA 155 (miR-155), Programmed Cell Death 4, and Activation Protein 1 Modulates the Expression of miR-155 and Tumorigenesis in Tongue Cancer. Mol Cell Biol. 2019 Mar 1;39(6). pii: e00410-18. PMID:30617160 IF-4.272
Kundu S, Ramshankar V, Verma AK, Thangaraj SV, Krishnamurthy A, Kumar R, Kannan R, Ghosh SK ⦁ Association of DFNA5, SYK, and NELL1 variants along with⦁ HPV infection in oral cancer among the prolonged tobacco-chewers. Tumour Biol. 2018 Aug;40(8):1010428318793023. PMID:30091681 IF-3.65
Scientific Meetings Conducted/planned - None Any Innovations:
Please feel free to contact our friendly staff with any medical enquiry.