MOLECULAR ONCOLOGY
PUBLICATION (2009-2014)

  1. Priya Ramanathan, Selvaluxmy Ganeshrajah, Rajalekshmi K.R, Shirley Sundar Singh, Thangarajan Rajkumar*. Development and clinical evaluation of dendritic cell vaccines for HPV related cervical cancer-a feasibility study. APJCP. 2014, 15. 5909-5916.

  2. Natarajan Valliyammai, Obul R Bandapalli, Rajkumar T, Sagar T.G, Nirmala K. Notch1 and Fbxw7 mutations in south Indian T- Acute Lymphoblastic Leukemia. J Ped Hematol/Oncol., 2014 Dec 9; PMID: 25493453 [ePub]

  3. Priya Ramanathan, Hemavathi Dhandapani, Hascitha Jayakumar, Selvaluxmy Ganeshrajah, Thangarajan Rajkumar. Dendritic Cells primed With HPV Positive Cervical Tumor Lysate Are Superior to Unprimed DC in migratory capacity and induce a potent Th1 response. Human Immunology 2014; 75:1216-1224. DOI information: 10.1016/j.humimm.2014.09.020

  4. Rawat A. Gopal G. Rajkumar T*. E4BP4 is a repressor of epigenetically regulatedSOSTDC1 expression in breast cancer cells. Cellular Oncology 2014;37[6]:409-419.doi

  5. Chen AA1, Heideman DA, Boon D, Gheit T, Snijders PJ, Tommasino M, Franceschi S, Clifford GM; IARC HPV Variant Study Group - Collaborators - Muñoz N, Herrero R, Bosch X, Hammouda D, Loria D, Matos E, Tshomo U, Dorji, Rios- Dalenz J, Eluf-Neto J, Ghadirian P, Ferreccio C, Ojeda J, Dai M, Li L, Wu R, Torroella M, Pearce N, Alibegashvili T, Kordzaia D, Keita N, Koulibaly M, Rajkumar T, Rajkumar R, Sarjadi, Khodakarami N, Sideri M, Gichangi P, De Vuyst H, Lee D-, Shin H, Bayo S, Dondog B, Chaouki N, Sherpa A, Thomas J, de los Rios E, Rolon P, Caceres E, Santos C, Ngelangel C, Bardin A, Zatonski W, Boye C, Toure-Kane C, Mbaye E, Diop-Ndiaye H, Moodley D, de Sanjose S, Castellsague X, Kitinya J, Chichareon S, Tunsakul S, Wabinga H, Aruhuri B, Frazer I. Human papilloma virus 45 genetic variation and cervical cancer risk worldwide. J Virol. 2014 Apr;88(8):4514-21. doi: 10.1128/JVI.03534-13.

  6. Combes JD, Pawlita M, Waterboer T, Hammouda D, Rajkumar T, Vanhems P, SnijdersP, Herrero R, Franceschi S, Clifford G. Antibodies against high-risk human papilloma virus proteins as markers for invasive cervical cancer. Int J Cancer. 2014 Apr 12. doi: 10.1002/ijc.28888. [Epub ahead of print] PubMed PMID: 24729277.

  7. Anantharaman D, Chabrier A, Gaborieau V, Franceschi S, Herrero R, Rajkumar T,Samant T, Mahimkar MB, Brennan P, McKay JD. Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India. PLoS One. 2014 Feb5;9(2):e88240. doi: 10.1371/journal.pone.0088240. eCollection 2014. PubMed PMID:24505444; PubMed Central PMCID: PMC3914962.

  8. Rawat A, Gopal G, Selvaluxmy G, Rajkumar T. Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole. Cell Oncol (Dordr). 2013.Dec;36(6):459-67. doi: 10.1007/s13402-013-0150-8. Epub 2013 Sep 27. PubMed PMID:24072565.

  9. Gopal G, Raja UM, Shirley S, Rajalekshmi KR, Rajkumar T. SOSTDC1 down-regulation of expression involves CpG methylation and is a potential prognostic marker in gastric cancer. Cancer Genet. 2013 May;206(5):174-82. doi:10.1016/j. cancergen.2013.04.005. Epub 2013 Jul 5. PubMed PMID: 23830730.

  10. Jully B, Vijayalakshmi R, Gopal G, Sabitha K, Rajkumar T. Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro. BMC Cancer. 2012 Nov 12;12:513. doi: 10.1186/1471-2407-12-513. PubMed PMID: 23145994; PubMed Central PMCID: PMC3519708.

  11. Jully B, Rajkumar T. Potential molecular targets for Ewing's sarcoma therapy. Indian J Med Paediatr Oncol. 2012 Oct;33(4):195-202. doi:10.4103/0971-5851.107074. PubMed PMID: 23580819; PubMed Central PMCID:PMC3618640.

  12. Bose MV, Gopisetty G, Selvaluxmy G, Rajkumar T. Dominant negative Ubiquitin-conjugating enzyme E2C sensitizes cervical cancer cells to radiation. Int J Radiat Biol. 2012 Sep;88(9):629-34. doi: 10.3109/09553002.2012.702299. Epub2012 Jul 4. PubMed PMID: 22694363.

  13. Raja UM, Gopal G, Rajkumar T. Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potentialserum biomarker. Asian Pac J Cancer Prev. 2012;13(11):5563-8. PubMed PMID:23317218.

  14. Gopal G, Shirley S, Raja UM, Rajkumar T. Endo-sulfatase Sulf-1 protein expression is down-regulated in gastric cancer. Asian Pac J Cancer Prev. 2012;13(2):641-6. PubMed PMID: 22524839.

  15. Sabitha K, Rajkumar T. Identification of small molecule inhibitors against UBE2C by using docking studies. Bioinformation. 2012;8(21):1047-58. doi:10.6026/97320630081047. Epub 2012 Oct 31. PubMed PMID: 23275705; PubMed CentralPMCID: PMC3524882.

  16. Lubin JH, Muscat J, Gaudet MM, Olshan AF, Curado MP, Dal Maso L, Wünsch-FilhoV, Sturgis EM, Szeszenia-Dabrowska N, Castellsague X, Zhang ZF, Smith E,Fernandez L, Matos E, Franceschi S, Fabianova E, Rudnai P, Purdue MP, Mates D,Wei Q, Herrero R, Kelsey K, Morgenstern H, Shangina O, Koifman S, LissowskaJ,Levi F, Daudt AW, Neto JE, Chen C, Lazarus P, Winn DM, Schwartz SM, BoffettaP,Brennan P, Menezes A, La Vecchia C, McClean M, Talamini R, Rajkumar T, Hayes RB,Hashibe M. An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies. Cancer Causes Control. 2011Sep;22(9):1217-31. doi: 10.1007/s10552-011-9792-x. Epub 2011 Jul 9. PubMed PMID:21744095; PubMed Central PMCID: PMC3304584.

  17. Sudhakar N, Rajalekshmy KR, Rajkumar T, Nancy KN. RT-PCR and real-time PCR analysis of E2A-PBX1, TEL-AML1, mBCR-ABL and MLL-AF4 fusion gene transcripts in de novo B-lineage acute lymphoblastic leukaemia patients in south India. J Genet.2011 Aug;90(2):349-53. PubMed PMID: 21869488.

  18. Peixoto A, Santos C, Pinheiro M, Pinto P, Soares MJ, Rocha P, GusmãoL,Amorim A, van der Hout A, Gerdes AM, Thomassen M, Kruse TA, Cruger D, SundeL,Bignon YJ, Uhrhammer N, Cornil L, Rouleau E, Lidereau R, Yannoukakos D, PertesiM, Narod S, Royer R, Costa MM, Lazaro C, Feliubadaló L, Graña B, Blanco I, de laHoya M, Caldés T, Maillet P, Benais-Pont G, Pardo B, Laitman Y, Friedman E,Velasco EA, Durán M, Miramar MD, Valle AR, Calvo MT, Vega A, Blanco A, DiezO,Gutiérrez-Enríquez S, Balmaña J, Ramon y Cajal T, Alonso C, Baiget M, FoulkesW,Tischkowitz M, Kyle R, Sabbaghian N, Ashton-Prolla P, Ewald IP, Rajkumar T,Mota-Vieira L, Giannini G, Gulino A, Achatz MI, Carraro DM, de Paillerets BB, Remenieras A, Benson C, Casadei S, King MC, Teugels E, Teixeira MR. International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation. Breast Cancer Res Treat. 2011 Jun;127(3):671-9. doi:10.1007/s10549-010-1036-3. Epub 2010 Jul 22. PubMed PMID: 20652400.

  19. Rajkumar T, Sabitha K, Vijayalakshmi N, Shirley S, Bose MV, Gopal G,Selvaluxmy G. Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer. 2011 Feb 22;11:80. doi: 10.1186/1471-2407-11-80.PubMed PMID: 21338529; PubMed Central PMCID: PMC3050856.

  20. Suneetha KJ, Nancy KN, Rajalekshmy KR, Rama R, Sagar TG, Rajkumar T. Role of glutathione-s-transferase and CYP1A1*2A polymorphisms in the therapy outcome of south Indian acute lymphoblastic leukemia patients. Indian J Med Paediatr Oncol.2011 Jan;32(1):25-9. doi: 10.4103/0971-5851.81886. PubMed PMID: 21731212; PubMedCentral PMCID: PMC3124985.

  21. Samson M, Singh SS, Rama R, Sridevi V, Rajkumar T. XPD Lys751Gln increasesthe risk of breast cancer. Oncol Lett. 2011 Jan;2(1):155-159. Epub 2010 Nov 23.PubMed PMID: 22870145; PubMed Central PMCID: PMC3412450.

  22. Rajkumar T, Vijayalakshmi N, Gopal G, Sabitha K, Shirley S, Raja UM, Ramakrishnan SA. Identification and validation of genes involved in gastric tumorigenesis. Cancer Cell Int. 2010 Nov 24;10:45. doi: 10.1186/1475-2867-10-45.PubMed PMID: 21092330; PubMed Central PMCID: PMC3004887.

  23. Rajkumar T. Personalized medicine: FAQs. Indian J Med Paediatr Oncol. 2010 Apr;31(2):72-4. doi: 10.4103/0971-5851.71661. PubMed PMID: 21209770; PubMedCentral PMCID: PMC2970940.

  24. Sasikala PS, Nirmala K, Sundersingh S, Mahji U, Rajkumar T. Frequency and distribution of Epstein-Barr virus infection and its association with P53expression in a series of primary nodal non-Hodgkin lymphoma patients from South India. Int J Lab Hematol. 2010 Feb;32(1 Pt 2):56-64. doi:10.1111/j.1751-553X.2008.01125.x. Epub 2009 Dec 4. PubMed PMID: 19055647.

  25. Rajkumar T, Vijayalakshmi N, Sabitha K, Shirley S, Selvaluxmy G, Bose MV,Nambaru L. A 7 gene expression score predicts for radiation response in cancer cervix. BMC Cancer. 2009 Oct 15;9:365. doi: 10.1186/1471-2407-9-365. PubMed PMID:19832977; PubMed Central PMCID: PMC2768747.

  26. Sudhakar N, Nancy NK, Rajalekshmy KR, Rajkumar T. Diversity of T-cell receptor gene rearrangements in South Indian patients with common acute lymphoblastic leukemia. Iran J Immunol. 2009 Sep;6(3):141-6. doi: IJIv6i3A4.PubMed PMID: 19801787.

  27. Soumittra N, Meenakumari B, Parija T, Sridevi V, Nancy KN, SwaminathanR,Rajalekshmy KR, Majhi U, Rajkumar T. Molecular genetics analysis of hereditary breast and ovarian cancer patients in India. Hered Cancer Clin Pract. 2009 Aug6;7(1):13. doi: 10.1186/1897-4287-7-13. PubMed PMID: 19656415; PubMed CentralPMCID: PMC2731042

  28. Nambaru L, Meenakumari B, Swaminathan R, Rajkumar T. Prognostic significance of HPV physical status and integration sites in cervical cancer. Asian Pac J Cancer Prev 2009 Jul-Sep;10(3):355-60. PubMed PMID: 19640172.

  29. Murhekar KM, Anuratha JN, Majhi U, Rajkumar T. Expression of human chorionic gonadotropin beta in gastric carcinoma: A retrospective immunohistochemical study. Indian J Med Paediatr Oncol 2009 Jul;30(3):99-102. doi:10.4103/0971-5851.64254. PubMed PMID: 20838545; PubMed Central PMCID: PMC2930296.

  30. Samson M, Rama R, Swaminathan R, Sridevi V, Nancy KN, Rajkumar T. CYP17(T34C), CYP19 (Trp39Arg), and FGFR2 (C906T) polymorphisms and the risk of breast cancer in south Indian women. Asian Pac J Cancer Prev 2009 Jan-Mar;10(1):111-4.PubMed PMID: 19469636.